Abstract
Tenofovir-associated renal toxicity is influenced by several factors, including plasma exposure and genetic variants in transporter-encoding genes. Tenofovir plasma exposure has been associated with a polymorphism in SLC28A2 gene (encoding the concentrative nucleoside transporter 2, CNT2): particularly, SLC28A2 124 CT/TT genotype patients show higher plasma tenofovir concentrations, compared to CC group.In literature, substrate studies are lacking; for this reason, our aim was to understand if tenofovir and tenofovir-alafenamide are CNT2 substrates.We performed an in vitro study using CNT2 expressing MDCKII cells.We observed that tenofovir and tenofovir-alafenamide are not substrates of CNT2.Tenofovir-alafenamide influx pathway remains to be clarified.
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