Abstract

Oral teneligliptin [Teneglucon® (Argentina)], a potent, selective dipeptidyl peptidase-4 (DPP-4) inhibitor, is a useful option to improve glycaemic control in patients with type 2 diabetes who have not responded adequately to treatment with diet and exercise, or the addition of biguanides, sulfonylureas or thiazolidinediones. In clinical trials, teneligliptin (20 or 40 mg once daily) monotherapy or combination therapy with metformin, glimepiride or pioglitazone, improved glycaemic control, including in patients with end-stage renal disease receiving haemodialysis. Improvements in glycaemic control were sustained after 52 weeks’ treatment. Teneligliptin is generally well tolerated, does not increase the risk of hypoglycaemia and is bodyweight neutral.

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