Tenecteplase for Acute Stroke

Abstract

For more than a decade, intravenous tissue plasminogen activator (TPA) has been the only approved pharmacological treatment for acute ischemic stroke. Tenecteplase, an investigational drug, is a modified version of TPA with greater fibrin specificity and a longer half-life. Researchers conducted this randomized, phase IIB trial to compare standard TPA with two doses of tenecteplase (0.1 mg/kg or 0.25 mg/kg) for patients seen at one of three centers within 6 hours of stroke onset. Inclusion criteria were standard clinical criteria, a computed …