Abstract
Ciprofloxacin is a broad-spectrum antibiotic from fluoroquinolones which are used to treat gram negative and positive bacterial infections. In last twenty years, tendinopathy is a worrying side effect. The side effects of tendon disorders including pain on tendon, angle tenderness, tendinitis and tendon rupture risk. Based on these symptoms various cases are shown and calculated. After several weeks pause in ciprofloxacin treatment the symptoms of tendon disorders are reduced.
Highlights
Ciprofloxacin is a broad spectrum antibacterial agent against gram negative bacteria and gram positive, anaerobic bacteria which belongs from the class of fluoroquinolones which are used for treatment of different bacterial infections ranging from urinary tract infections to respiratory tract infections [1,2,3]
The results shows that ciprofloxacin can have negative effects on tendon through the mechanism by up regulating gelatinase expression and it was confirmed by the evidence of increased degradation of type I collagen [15]
This review illustrates that ciprofloxacin has some negative effect upon tendon structure
Summary
Ciprofloxacin is a broad spectrum antibacterial agent against gram negative bacteria and gram positive (recently), anaerobic bacteria which belongs from the class of fluoroquinolones which are used for treatment of different bacterial infections ranging from urinary tract infections to respiratory tract infections [1,2,3]. It functions by inhibiting DNA gyrase and a type II topoisomerase, topoisomerase IV, necessary to separate bacterial DNA, thereby, inhibiting cell divisions [4,5,6]. The possible proposed mechanisms are effects of ciprofloxacin on expression of MMP-2,9, TIMP-1,2 and tissue inhibitor type I collagen in tendon cells and decrease in interleukin1-β [15,16]
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