Abstract
The fine structure of tendon fibroblasts in developing limbs of chick and mouse embryos have been examined to define the cellular features of collagen fibrillogenesis in vivo . Two structural features of the fibroblast which may relate to fibril assembly have been observed: intracellular aggregates resembling SLS (segment-long-spacing)-like aggregates of monomeric and dimeric lengths and deep recesses of the cell surface containing striated fibrils. A model is proposed which suggests that assembly of a collagen fibril in vivo begins by formation of subassemblies inside the cell which then are excreted by exocytosis and added to a unique region at the fibril end. This end is closely associated with the cell surface in a manner which allows for cellular regulation of some parameters of fibril morphology.
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