Abstract
Cardiac magnetic resonance imaging (MRI) has been largely dependent on retrospective cine for data acquisition. Real-time imaging, although inferior in image quality to retrospective cine, is more informative about motion dynamics. We herein developed a real-time cardiac MRI approach to temporospatial characterization of left ventricle (LV) and right ventricle (RV) wall motion. This approach provided two temporospatial indices, temporal periodicity and spatial coherence, for quantitative assessment of ventricular function. In a cardiac MRI study, we prospectively investigated temporospatial characterization in reference to standard volumetric measurements with retrospective cine. The temporospatial indices were found to be effective for evaluating the difference of ventricular performance between the healthy volunteers and the heart failure (HF) patients (LV temporal periodicity 0.24 ± 0.037 vs. 0.14 ± 0.021; RV temporal periodicity 0.18 ± 0.030 vs. 0.10 ± 0.014; LV spatial coherence 0.52 ± 0.039 vs. 0.38 ± 0.040; RV spatial coherence 0.50 ± 0.036 vs. 0.35 ± 0.035; all in arbitrary unit). The HF patients and healthy volunteers were well differentiated in the scatter plots of spatial coherence and temporal periodicity while they were mixed in those of end-systolic volume (ESV) and ejection fraction (EF) from volumetric measurements. This study demonstrated the potential of real-time cardiac MRI for intricate analysis of ventricular function beyond retrospective cine.
Highlights
Cardiac magnetic resonance imaging (MRI) has been largely dependent on retrospective cine for data acquisition
It was experimentally found that the temporospatial indices detected the difference of ventricular performance between the healthy volunteers and the heart failure (HF) patients
This demonstrated the potential of temporospatial characterization with real-time cardiac MRI for quantitative assessment of ventricular function
Summary
Cardiac magnetic resonance imaging (MRI) has been largely dependent on retrospective cine for data acquisition. We developed a real-time cardiac MRI approach to temporospatial characterization of left ventricle (LV) and right ventricle (RV) wall motion This approach provided two temporospatial indices, temporal periodicity and spatial coherence, for quantitative assessment of ventricular function. Retrospective cine can collect data from several cardiac cycles with breath-holding and sort them into a virtual cardiac cycle in reference to electrocardiogram (ECG) gating during post processing[3,4] This technique provides a set of single-cycle multi-phase images for quantitative analysis with an assumption that the heartbeat variation be minor across different cardiac cycles. Real-time images are more informative because they permit visualization of the temporal and spatial behaviors of cardiac motion over a series of sequential cardiac cycles This multi-cycle temporospatial information, potentially beneficial to ventricular function assessment, has not been investigated extensively in cardiac MRI studies
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