Abstract
Monaural chinchillas trained in behavioral audiometry, were used to test the hypothesis that the combined effects of noise and sodium salicylate intoxication produce a larger loss of hearing sensitivity or temporary threshold shift (TTS) than either agent alone can produce. The hypothesis was confirmed in that, while the TTS due to broad-band noise exposure of 85-dB intensity was 35 dB on the average, and the TTS, due to prolonged serum salicylate levels of approximately 20-40 mg%, was 33 dB on the average, the combination of noise and salicylate exposure produced a TTS of 55 dB on the average.
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