Abstract
MICE injected with lymphocytic choriomeningitis (LCM) virus generate specifically sensitised thymus-derived (T) lymphocytes1–3. Such cells have been shown1,2,4 in in vitro 51Cr-release assays to be cytotoxic to target cells infected with LCM virus. The specificity of the cytotoxic reaction has been inferred by the observation that the cytotoxic T lymphocytes (CTL) do not lyse noninfected target cells. Moreover, there is evidence that the activity of the CTLs generated is restricted to those virus infected target cells which are compatible with the CTLs in regard to the major histocompatibility complex (MHC)5. This peculiar restriction prompted us to study the specificity of CTLs generated in murine LCM. We observed that 4–6 d after infection with the LCM virus the CTLs generated are specifically cytotoxic to syngeneic target cells, irrespective of whether or not they are infected with LCM virus. On the other hand, as the infection proceeds in time, T-cell mediated cytotoxicity is increasingly restricted to virus-infected syngeneic cells. The results imply that during the early phase after infection, murine LCM may represent an autoimmune phenomenon.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
