Abstract

Body NaCl was temporarily sequestered in the peritoneal cavity by injecting a load (2, 4, 8, or 10% body weight) of isotonic glucose (intraperitoneal dialysis). A load-size related increase in 0.5 M NaCl solution ingestion occurred for the following 3 days. At this time a second dialysis resulted in an even greater NaCl solution intake for the next 3 days. Temporary sequestration of body NaCl in the peritoneal cavity is a sufficient condition for the production of a persisting (at least 3 days) increase in the intake of a highly hypertonic NaCl solution. Actual depletion of body NaCl by removal of the dialysate from the animal was not a necessary condition for the production of a persisting NaCl appetite.

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