Abstract
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Highlights
Habituation is a highly conserved behavioral modification whereby responses to repetitive or continuous stimuli not associated with concurrent salient stimuli or events are attenuated (Harris, 1943)
We initially focused on the antennal lobe local interneurons (LNs), which are mostly (95%) GABAergic, activated both by sensory and projection neurons, and modulate Projection Neurons (PNs) output (Silbering et al, 2008; Tanaka et al, 2012)
Together with the GH146Gal4 silencing experiments, these results indicate that innervation of the Mushroom Bodies (MBs) and Lateral Horn (LH) by excitatory iACT neurons, but not the mACT PNs, is essential to sustain habituation latency and prevent premature habituation to brief continuous odor exposure
Summary
Habituation is a highly conserved behavioral modification whereby responses to repetitive or continuous stimuli not associated with concurrent salient stimuli or events are attenuated (Harris, 1943). Habituation devalues the salience of a stimulus permitting animals to attend other, potentially more significant stimuli. Preventing premature habituation is essential to maintain information content long enough to allow association with other stimuli. This led to the notion that habituation is a ‘building block for associative learning’. Habituation paradigms have been used to assess cognitive abilities (Chard et al, 2014) and recent studies indicate that genes involved in intellectual disability are linked to impaired habituation (Lugtenberg et al, 2016; Stessman et al, 2016). The implication of habituation in multiple cognitive disorders and its potential effects on associative learning highlight the significance of understanding the molecular mechanisms and neuronal circuitry that govern it
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