Abstract
Recent experimental data have characterized a form of long-term synaptic modification that depends on the relative timing of pre- and post-synaptic action potentials. Modeling studies indicate that this rule can automatically adjust excitatory synaptic strengths so that the post-synaptic neuron receives roughly equal amount of excitation and inhibition and as a consequence fires irregular spike trains as observed in vivo. This rule also induces competition between different inputs and strengthens groups of synapes that are correlated over short time periods.
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