Temporally advanced dynamic change of receptive field of lateral geniculate neurons during brief visual stimulation: Effects of brainstem peribrachial stimulation

Abstract

Processing of visual information in the brain seems to proceed from initial fast but coarse to subsequent detailed processing. Such coarse-to-fine changes appear also in the response of single neurons in the visual pathway. In the dorsal lateral geniculate nucleus (dLGN), there is a dynamic change in the receptive field (RF) properties of neurons during visual stimulation. During a stimulus flash centered on the RF, the width of the RF-center, presumably related to spatial resolution, changes rapidly from large to small in an initial transient response component. In a subsequent sustained component, the RF-center width is rather stable apart from an initial slight widening. Several brainstem nuclei modulate the geniculocortical transmission in a state-dependent manner. Thus, modulatory input from cholinergic neurons in the peribrachial brainstem region (PBR) enhances the geniculocortical transmission during arousal. We studied whether such input also influences the dynamic RF-changes during visual stimulation. We compared dynamic changes of RF-center width of dLGN neurons during brief stimulus presentation in a control condition, with changes during combined presentation of the visual stimulus and electrical PBR-stimulation. The major finding was that PBR-stimulation gave an advancement of the dynamic change of the RF-center width such that the different response components occurred earlier. Consistent with previous studies, we also found that PBR-stimulation increased the gain of firing rate during the sustained response component. However, this increase of gain was particularly strong in the transition from the transient to the sustained component at the time when the center width was minimal. The results suggest that increased modulatory PBR-input not only increase the gain of the geniculocortical transmission, but also contributes to faster dynamics of transmission. We discuss implications for possible effects on visual spatial resolution.