Temporal variation of tryptase and interlaboratory variability

Abstract

The diagnosis of anaphylaxis and mast cell activation syndrome (MCAS) relies largely on history with laboratories assisting in diagnosis as an objective demonstration of mast cell activation.1-3 Serum tryptase is the most readily available and typically used marker in this regard.4 Consensus expert opinion recommends using an objective rise in mast cell mediators as a requirement for the diagnosis of MCAS, and 1 equation that is typically used is an increase in serum tryptase level above the individual's baseline of 20% plus 2 ng/mL.