Abstract
The neural processing loop of language is complex but highly associated with Broca's and Wernicke's areas. The left dominance of these two areas was the earliest observation of brain asymmetry. It was demonstrated that the language network and its functional asymmetry during resting state were reproducible across institutions. However, the temporal reliability of resting-state language network and its functional asymmetry are still short of knowledge. In this study, we established a seed-based resting-state functional connectivity analysis of language network with seed regions located at Broca's and Wernicke's areas, and investigated temporal reliability of language network and its functional asymmetry. The language network was found to be temporally reliable in both short- and long-term. In the aspect of functional asymmetry, the Broca's area was found to be left lateralized, while the Wernicke's area is mainly right lateralized. Functional asymmetry of these two areas revealed high short- and long-term reliability as well. In addition, the impact of global signal regression (GSR) on reliability of the resting-state language network was investigated, and our results demonstrated that GSR had negligible effect on the temporal reliability of the resting-state language network. Our study provided methodology basis for future cross-culture and clinical researches of resting-state language network and suggested priority of adopting seed-based functional connectivity for its high reliability.
Highlights
Broca’s and Wernicke’s areas are two major regions associated with language processing
We investigated the functional asymmetry of resting-state language network and its TRT reliability
Resting-state Functional connectivity and asymmetry As we focused on the cortical regions which functionally correlated with Broca’s and Wernicke’s areas, we estimated the Restingstate functional connectivity (RSFC) maps for each subject and each functional scan using the standard seed-based correlation analysis
Summary
Broca’s and Wernicke’s areas are two major regions associated with language processing (see review [1]). The damage of Broca’s area has been shown to result in Broca’s aphasia [3]. Broca’s and Wernicke’s areas are involved in a neural language processing loop [5] and locate at different end of this loop. This neural model of language processing has been demonstrated by many studies (see review [6]), and it is shown that more regions are correlated with this neural processing model besides Broca’s and Wernicke’s areas [7,8,9]
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