Abstract
The temporal changes in progesterone (Δ 4P), 20α-dihydroprogesterone (20α-DHP) and luteinizing hormone (LH) concentrations in pseudopregnant (PSP) rats after treatment with a single subcutaneous Silastic-PUP tube containing 600 μg PGF 2α were correlated. Progesterone levels fell and LH levels rose significantly 2h after initiation of treatment, while 20α-DHP levels were fond to increase significantly 12h after treatment. Since the changes in Δ P and LH concentrations occurred concurrently, it seems that the increase in LH levels could have been due to a direct effect of PGF2a on the ovary causing a reduction in Δ 4P and thus a negative feedback effect on LH release. Alternatively, PGF2a might exert a direct effect on LH secretion at the hypothalamic-pituitary level.
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