Abstract
This study utilized 2D-PAGE and MALDI-ToF to investigate labor-associated temporal protein changes in the human cervicovaginal fluid (>25 kDa). Monocyte/neutrophil elastase inhibitor, squamous cell carcinoma antigen 1, annexin A3, collagen and albumin demonstrated differential expression prior to and/or during term labor. These findings provide further insight into the extracellular matrix remodeling of the cervix and overlying fetal membranes and may be useful to develop predictive tools for labor.
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