Abstract
Temporal interference (TI) stimulation is a novel electrical stimulation technique which offers noninvasive deep brain stimulation (NDBS) in mice. The purpose of this study is to investigate the effect of TI stimulation on deep layers superior colliculus (SC) nerve activity and eye movements in mice. Six male C57BL / 6J mice were used in this study. Different parameters of TI stimulation were applied to the deep layers of mice SC. Each TI stimulation lasted for 20 seconds and were repeated five times. We analyzed the synchronous recording of Ca2+ signals in deep layers mice SC and the eye movement amplitudes. Our results show that TI stimulation can evoke eye movements and the neural activity in deep layers of mice SC. Changing the difference frequency of TI stimulation can regulate the frequency of the nerve activity and eye movements. Granger causality analysis indicates that the neural activity in deep layers of mice SC may cause the eye movements during TI stimulation.
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