Temporal integration on the dendrites of fast-spiking basket cells

Abstract

Neurons receive synaptic inputs with diverse temporal patterns in vivo, and their integration of these patterns is critical for understanding information processing mechanisms in the brain. Fast-spiking basket cells, which perform both supralinear and sublinear dendritic integration, are essential for inhibitory control in the hippocampus. However, their responses and the mechanisms underlying different temporal input patterns remain unclear. To address this question, we apply inputs with varying windows of time to a detailed compartmental model of basket cells. Our results reveal that when synaptic inputs are randomly dispersed, temporal integration in FS BCs exhibits a sigmoid-like response within the temporal window. In contrast, synchronous input protocols more effectively elicit action potentials, while asynchronous inputs generate more spikes in response to suprathreshold stimuli. Further analysis shows that the supralinear dendrites of fast-spiking basket cells primarily mediate this nonlinearity to asynchronous inputs, owing to their larger dendritic diameters. Moreover, we discover that delayed rectifier channels reduce sensitivity to synchronous inputs, whereas N-type channels enhance sensitivity to asynchronous inputs. These results provide insights into the mechanisms underlying the temporal coding of fast-spiking basket cells, which is crucial for understanding their role in neuronal oscillations.