Temporal difference modelling of aversive conditioning and extinction: An fMRI study

Abstract

Event Abstract Back to Event Temporal difference modelling of aversive conditioning and extinction: An fMRI study Niels Petter Sigvartsen1* and Jimmy Jensen2 1 University of Oslo, Norway 2 University of Oslo, Oslo University Hospital, Norway The prediction error (PE) signal from temporal difference (TD) models have been shown to correlate with activity in specific brain regions in both human and animals during conditioning tasks. One of the key regions involved is the ventral striatum (VS). The purpose of this study was to investigate how the TD model predicted VS activations during aversive conditioning and extinction. Functional Magnetic Resonance Imaging (fMRI) Blood-Oxygen Level Dependent (BOLD) data were acquired on a 1.5 T GE Signa scanner. Thirty-three healthy subjects completed a 33% partially reinforced classical conditioning paradigm using coloured circles as the conditioned stimulus (CS) and aversive cutaneous electrical stimulation (CES) as the unconditioned stimulus (US). After a short break a second scanning session was performed where the subjects were divided into three groups (N=11 in each group): 1) a control group that repeated the paradigm; 2) an extinction group that repeated the paradigm with the CES turned off without their knowledge; and 3) an intervention group that were told that the CES would be turned off before they repeated the paradigm. Thus, in the second session the extinction and intervention groups saw the CS but without US. A modified TD algorithm was used to generate a salience PE signal vector which was used as a regressor in the fMRI analyses. Pre-processing and analyses of data were done using SPM5. Final analysis of the first session and preliminary analysis of the control and extinction groups from the second session are reported here. Analysis of the first session included all 33 subjects and PE activations bilaterally in the VS, anterior insula and anterior cingulate were obtained. Analyses from the second session showed that activations were predicted by salience PE bilaterally in the VS and the anterior insula in the control group while the extinction group recruited the VS and the ventro-medial PFC. The findings from the first session and the control group in the second session replicated previous studies. However, the results of the second session in the extinction group extend that fMRI BOLD behave according to salience PE to a more general level in aversive learning ranging from acquisition to maintenance to extinction of associations. Conference: Neuroinformatics 2009, Pilsen, Czechia, 6 Sep - 8 Sep, 2009. Presentation Type: Poster Presentation Topic: Neuroimaging Citation: Sigvartsen N and Jensen J (2019). Temporal difference modelling of aversive conditioning and extinction: An fMRI study. Front. Neuroinform. Conference Abstract: Neuroinformatics 2009. doi: 10.3389/conf.neuro.11.2009.08.025 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 21 May 2009; Published Online: 09 May 2019. * Correspondence: Niels Petter Sigvartsen, University of Oslo, Oslo, Norway, n.p.b.sigvartsen@medisin.uio.no Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Niels Petter Sigvartsen Jimmy Jensen Google Niels Petter Sigvartsen Jimmy Jensen Google Scholar Niels Petter Sigvartsen Jimmy Jensen PubMed Niels Petter Sigvartsen Jimmy Jensen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.