Abstract
Cerebral autoregulation is the mechanism by which constant cerebral blood flow is maintained despite changes in arterial blood pressure. In the two presented cases, cerebral autoregulation was impaired in patients with narcolepsy type 1, and both venlafaxine and fluoxetine may have the potential to improve the impaired cerebral autoregulation. A relationship may exist between impaired cerebral autoregulation and neurological symptoms in patients with narcolepsy type 1.
Highlights
Narcolepsy type 1, one of the two types of narcolepsy, is characterized by excessive daytime sleepiness and cataplexy with rapid and easy entry into rapid eye movement (REM) sleep [1]
Cerebral autoregulation, which is defined as the mechanism by which constant cerebral blood flow is maintained despite changes in arterial blood pressure, is critical in regulating cerebral hemodynamics and plays an important role in many neurologic diseases [3,4,5,6,7,8]
Cerebral autoregulation was obviously impaired in both patients with narcolepsy type 1, and both venlafaxine and fluoxetine improved the impaired cerebral autoregulation
Summary
Narcolepsy type 1, one of the two types of narcolepsy, is characterized by excessive daytime sleepiness and cataplexy with rapid and easy entry into rapid eye movement (REM) sleep [1]. His clinical symptoms were relieved, and his Epworth sleep scale was 10 His cerebral autoregulation improved and became normal (phase difference, 61 degrees in the left and 63 degrees in the right). After 1 month, his clinical symptoms were relieved, his Epworth sleep scale was 9, and his cerebral autoregulation again improved and became normal (phase difference, 58 degrees in the left and 53 degrees in the right, Figure 2). This patient was an otherwise healthy 17-years-old male. His cerebral autoregulation improved clearly (74 degrees in the left and 68 degrees in the right, Figure 3)
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