Abstract
IT IS NOT KNOWN if and to what extent transfusion in coronary artery bypass graft (CABG) surgery has changed over time in the United States, considering the publication of national guidelines 1 Ferraris V.A. Ferraris S.P. Saha S.P. et al. Perioperative blood transfusion and blood conservation in cardiac surgery: The Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guideline. Ann Thorac Surg. 2007; 83: S27-S86 Abstract Full Text Full Text PDF PubMed Scopus (772) Google Scholar and the suspension of marketing of aprotinin 2 Pharmaceuticals B.H. Bayer Temporarily Suspends Global Trasylol Marketing. http://www.trasylol.com/Trasylol_11_05_07.pdf Google Scholar associated with negative publications related to its safety. 3 Mangano D.T. Miao Y. Vuylsteke A. et al. Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. JAMA. 2007; 297: 471-479 Crossref PubMed Scopus (331) Google Scholar , 4 Mangano D.T. Tudor I.C. Dietzel C. The risk associated with aprotinin in cardiac surgery. N Engl J Med. 2006; 354: 353-365 Crossref PubMed Scopus (964) Google Scholar , 5 Shaw A.D. Stafford-Smith M. White W.D. et al. The effect of aprotinin on outcome after coronary artery bypass grafting. N Engl J Med. 2008; 358: 784-793 Crossref PubMed Scopus (173) Google Scholar , 6 Fergusson D.A. Hebert P.C. Mazer C.D. et al. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med. 2008; 358: 2319-2331 Crossref PubMed Scopus (890) Google Scholar
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