Abstract
The serum levels of progesterone ( Δ 4P), 20α-dihydroxyprogesterone (20α-DHP), pregnenolone ( Δ 5P) and estrogens at different time intervals during Silastic-PVP-PGF 2α tube induced midterm abortion were measured by radioimmunoassay in the rat and rabbit. The concentrations of 4P and Δ 5P were significantly reduced but that of 20α-DHP was increased significantly as early as 20 hours after PGF 2α treatment. Estrogen levels showed slight reduction in the rat but remained unchanged in the rabbit. The ratio of Δ 4P/20 α-DHP recorded were 2.15 and 16.86 (pretreatment) and dropped to 0.08 and 0.37 (60 hours after insertion of Silastic-PVP-PGF 2α tube) in the rat and rabbit, respectively. These findings suggest that the suppression of circulating Δ 4P by PGF 2α might be the result of a reduced precursor ( Δ 5P) pool size as well as changes in the enzymic systems responsible for the formation and conversion of Δ 4P. It is still to be determined if changes in estrogen levels in the rat have any bearing on abortion induced by PGF 2α.
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