Abstract
This retrospective, nationwide, matched cohort study investigated the temporal relationship of central serous chorioretinopathy (CSCR) following topical ophthalmic corticosteroid (TOC) use. Using the Longitudinal Health Insurance Database 2000 (LHID2000), we collected patients diagnosed with CSCR between January 2001 and December 2010 (n = 2921) and a control group (n = 17,526). Information for each patient was collected and tracked from the index date until December 2011. TOC users were classified based on (i) the date of the last prescription before diagnosis: current users (≤30 days) and former users (31–182 days and ≥183 days) and (ii) the prescription refill intervals: persistent users (interval ≤90 days) and non-persistent users (interval >90 days). The odds ratio (OR) was estimated from multivariate conditional logistic regression after adjusting for relevant confounders. After adjusting for age, sex, geographic region, index date, previously known comorbidities, the date of last TOC prescription before diagnosis, or prescription refilling intervals, the results revealed that patients were likely to have developed CSCR while using TOCs currently (OR = 30.42, 95% CI = 25.95–35.66, p < 0.001) and persistently (OR = 7.30, 95% CI = 6.13–8.69, p < 0.001) as compared to the controls. Our results indicate that current or persistent TOCs use increases the risk of CSCR. Thus, patients requiring TOCs should be advised of this risk, particularly in current or persistent use conditions.
Highlights
Central serous chorioretinopathy (CSCR) is a major cause of vision threat characterized by serous neurosensory retinal detachments and/or retinal pigment epithelium (RPE) detachment [1,2]
It is worth noting in particular that we have previously demonstrated the role of topical ophthalmic corticosteroid (TOC) administration in the development of CSCR [25]
After stratifying CSCR and control groups according to the comorbidities, we found that the adjusted odds ratio (OR) in CSCR with peptic ulcer or coronary artery disease were statistically significant
Summary
Central serous chorioretinopathy (CSCR) is a major cause of vision threat characterized by serous neurosensory retinal detachments and/or retinal pigment epithelium (RPE) detachment [1,2]. These changes are mostly confined to the macula and are linked to the leakage of fluid from the RPE into the subretinal space. CSCR mostly affects adults, especially young and middle-aged men, Int. J. Res. Public Health 2020, 17, 9455; doi:10.3390/ijerph17249455 www.mdpi.com/journal/ijerph
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