Temporal assessment of airway remodeling in severe asthma using quantitative computed tomography.

Sumit Gupta,Amisha Singapuri,Beverly Hargadon,James J Entwisle,Ruth Hartley,Richard P Marshall,William Monteiro,Deepak Subramanian,Salman Siddiqui,Vimal Raj,Ana R Sousa,David Parr,Ian D Pavord,Christopher E Brightling

doi:10.1164/rccm.201406-1128le

Abstract

Temporal assessment of airway remodeling in severe asthma using quantitative computed tomography.

Highlights

When the subjects with severe asthma were split into previously described QCT-derived clusters [3], the mean (SEM) change in interval normalized RB1 WA/BSA
We have previously shown a decrease in RB1 WA/BSA in subjects with severe asthma after 1 year of treatment with anti–IL-5 compared with placebo, with an approximately 10% between-group change [7]
A longitudinal study in subjects with severe asthma has demonstrated that in a multivariate regression model baseline % WA was a predictor of subsequent airway remodeling [14]

Summary

Introduction

RB1 wall area (WA)/body surface area (BSA) demonstrated a significant increase over time (mean [SEM]: first CT, 14.3 [0.9]; second CT, 14.7 [0.9]; third CT, 16.5 [1.3] mm2/m2; repeated measure analysis of variance [ANOVA], P = 0.008). No significant change was seen in RB1 lumen area (LA)/BSA When the subjects with severe asthma were split into previously described QCT-derived clusters [3], the mean (SEM) change in interval normalized RB1 WA/BSA

Objectives

Results

Conclusion