Temporal and spatial transitions in collagen types during embryonic chick limb development: II. Comparison of the embryonic cartilage collagen molecule with that from adult cartilage

Abstract

Analyses were performed to compare the (α1) 3 collagen molecule synthesized by the cartilaginous long bone anlage of 8-day chick embryos with that produced by adult cartilage, [α1(II)] 3. The embryonic molecule produced segment-long-spacing crystallites which had a banding pattern indistinguishable from that of authentic [α1(II)] 3. After carboxymethyl cellulose chromatography, the material in the α1 chain peak of the embryonic collagen was found to have the same amino acid composition as that of the α1(II) chain.