Abstract
Objective: Acute renal failure (ARF) and hypertension as a comorbid disorders can be found frequently in intensive care unit patients. The aim of our study was to investigate the antihypertensive effects of 4-Hydroxy-2, 2, 6, 6-tetramethylpiperidine-N-oxyl (tempol), synthetic SOD mimetic, on regional haemodynamics in the course of ARF in hypertension. Design and Method: Experiment was performed in anesthetized, six-month-old male spontaneously hypertensive rats (SHR). The right kidney was removed and ARF was induced by clamping the left renal artery for 40 minutes. SHR were divided in 3 experimental groups: sham operated group (SHAM; n = 7); ARF group (ARF; n = 9); and ARF group with tempol treatment (40 mg/kg/h) (ARF+TEM; n = 8). Tempol was given by infusion during the period of three hours after reperfusion. Mean arterial pressure (MAP), carotid blood flow (CBF) and renal blood flow (RBF) were measured and carotid vascular resistance (CVR) and renal vascular resistance (RVR) was calculated 24 h after reperfusion.Conclusion: Our results indicate that in hypertension free oxygen species contribute to renal vasoconstiction, one of the major pathophysiological mechanism of postischemic ARF.
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