Abstract
No medical or surgial treatments have been reported to permanently stop trigeminal pain attacks. TEMPOL, a stable nitroxide radical scavenger, has been recently shown efficient in providing neuroprotection. Here we tested the efficiency of TEMPOL in alleviating heat hyperalgesia and expression of NADPH-d in trigeminal afferent neurons of rats with experimentally induced secondary trigeminal neuralgia by chronic constriction of infraorbitary nerve. The results showed that TEMPOL significantly reduced heat hyperalgesia and induced a large decrease of NADPH-d in neurons of the Gasser ganglia. These findings suggest that the radical scavengers like TEMPOL could be new therapeutic strategies to treat neuropathic pain induced by infraorbital nerve constriction.
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