Abstract
Short, histidine-containing peptides can be conjugated to lysine-containing protein scaffoldsto controllably attach quantum dots (QDs) to the scaffold, allowing for generic attachmentof quantum dots to any protein without the use of specially engineered domains.This technique was used to bind quantum dots from aqueous solution to bothchicken IgG and cowpea mosaic virus (CPMV), a 30 nm viral particle. Thesequantum dot–protein assemblies were studied in detail. The IgG–QD complexeswere shown to retain binding specificity to their antigen after modification. TheCPMV–QD complexes have a local concentration of quantum dots greater than3000 nmol ml−1, and show a 15% increase in fluorescence quantum yield over free quantum dots insolution.
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