Abstract
AbstractWe report on the synthesis of bivalent water‐soluble calix[4]arene and calix[5]arene hosts, Super‐sCx4 and Super‐sCx5 as new broad‐spectrum supramolecular binders of neuromuscular blocking agents (NMBAs). Synthesis was achieved using the target bisquaternary amine NMBAs as a template to link two highly anionic p‐sulfonatocalixarene building blocks in aqueous solution. Bivalent anionic hosts Super‐sCx4 and Super‐sCx5 bind by engaging both quaternary amines present on a variety of NMBAs. We report low μM binding to structurally diverse alkyl, steroidal, curarine and benzylisoquinoline NMBAs with high selectivity over the neurotransmitter acetylcholine and a variety of other hydrophobic amines.
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