Abstract
The effect of various pre- and postirradiation conditions on the yield of temperature-sensitive ( ts) and ordinary lethal mutations is described, and compared with the results of earlier work in Paramecium aurelia. Certain conditions, such as stage in the division or growth cycle, streptomycin treatment, and postirradiation starvation, affect the yield of ts and ordinary lethals in the same way, and these are the conditions that might be expected to influence mutation fixation through repair of premutational damage. With clonal age, and under similar conditions, there appears to be a conversion of temperature-sensitive mutations into lethal mutations, a conversion which might be expected from the different physiological changes occurring in aging paramecia.
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