Abstract
Fever in neutropenia (FN) is the most frequent potentially lethal complication of chemotherapy in patients with cancer. The temperature limit defining fever (TLDF) for FN is based on scarce evidence. This prospective, single center observational study recruited non-selected pediatric patients diagnosed with cancer between ≥1 and ≤17 years in 2012 and 2013. Of 40 patients potentially eligible, 39 participated. Data of 8896 temperature measurements and 1873 complete blood counts (CBCs) were recorded over 289 months (24.1 years) of chemotherapy exposure time. During this time 43 FN episodes were diagnosed. In 32 episodes, FN diagnosis was based on reaching the local (i.e. Bern, Switzerland) standard TLDF of 39.0 °C; another 11 episodes had been captured by clinical judgement (i.e. temperature < 39.0 °C). These data can be used to simulate the effects of various TLDFs on the rate of FN diagnosis. We assume merging these data with other data sets is feasible.
Highlights
Background & SummaryFever in chemotherapy-induced neutropenia (FN) is the most frequent potentially lethal complication of chemotherapy in pediatric and adult patients with cancer and should be managed as a medical emergency
The data described here[9] had been collected during a prospective observational study (August 11, 2012 to May 31, 2013) in pediatric patients diagnosed with cancer between ≥1 to ≤17 years and treated with chemotherapy in a single center (Bern, Switzerland) applying a standard temperature limit defining fever (TLDF) of 39.0 °C ear temperature (NCT01683370)
In 1032 complete blood counts (CBCs) the absolute neutrophil count (ANC) reached >1.0 G/L and in 162 (9%) it was unknown[8]. These data can be used to simulate the effects of various TLDFs on the rate of Fever in neutropenia (FN) diagnosis
Summary
Background & SummaryFever in chemotherapy-induced neutropenia (FN) is the most frequent potentially lethal complication of chemotherapy in pediatric and adult patients with cancer and should be managed as a medical emergency. The data described here[9] had been collected during a prospective observational study (August 11, 2012 to May 31, 2013) in pediatric patients diagnosed with cancer between ≥1 to ≤17 years and treated with chemotherapy in a single center (Bern, Switzerland) applying a standard TLDF of 39.0 °C ear temperature (NCT01683370). The study was powered to determine the rate of FN episodes diagnosed by lower versus standard TLDFs. Analytical results on
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
