Abstract
AbstractA novel class of bio‐based 4‐hydroxy‐2‐pyridones was synthesized via Mannich reaction under solvent free conditions in absence any catalyst at room temperature. Interestingly, in thermal condition, the yields of these products were decreased and others products (from condensation of two molecules of 2‐pyridone and one molecule of aldehyde) were obtained. Then the antioxidant activity of the synthesized compounds were evaluated by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging assay methods. In general all of products showed significant radical scavenging potential, but the derivatives of pyrrolidine were more significant effective than the piperidine derivatives. This protocol provides a convenient, room temperature, solvent‐free, and catalyst‐free access to new 3‐substituted‐4‐hydroxy‐2‐pyridones.
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