Abstract

The temperature sensitivity of fast axonal transport of labeled protein in peripheral sensory axons was investigated in rats and hibernating and non-hibernating ground squirrels ( Spermophilus r. richardsonii), using an in vitro technique which permitted incubation of the sciatic nerve for various periods of time at different temperatures. The relationship between velocity and temperature was exponential between 13 and 38°C, but below 13°C transport ceased or became too slow to detect. There were no significant differences in the relationship between temperature and velocity for the three classes of nerve studied. It is concluded that the peripheral nerves of hibernating ground squirrels are not modified to permit axonal transport to continue at the low body temperatures characteristic of the hibernating state.

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