Temperature-Sensitive Nanogels PNIPAAm/DMA Prepared and Research

Abstract

There have much study about thermo-responsive nanogels,which exhibit temperature-controlled volume phase transitions.There have been few reports,however,of electrostatically neutral,thermosensitive nanogels with a high composition of hydrophilic monomer.Here,we describe the synthesis and characterization of a new class of nonionic copolymer nanogels based on N-ispropylacrylamide(NIPAM) and N,N-dimethylacrylamide(DMA),wich exhibit tunable volume phase transition temperatures.And increasing percentages of DMA in copolymer gels raises the LCST,and attenuates and broadens the volume phases transition.Through DLS, AFM and UV-Vis measurement it's size,shape and VPTTs.The character of nonionic NIPAM/DMA nanogels show it's tunable phase transitions promise to be useful for applicatipns in biotechnology and medicine.