Abstract

Gadolinium salts have been used as contrast agents from the early days of neutron radiography because of the extremely high neutron absorption cross section of gadolinium. Gadolinium salts, such as the chloride and the nitrate, are generally very soluble in water but are also often hygroscopic and corrosive. This work reports a series of gadolinium chelates based on gadolinium acetylacetonate that were adapted for use as contrast agents. The chelates are soluble in a variety of volatile organic solvents such as methylene chloride and acetone. In addition, some are thermally stable in the absence of oxygen and water, and by observing when they melt or vaporize, they can be used as temperature indicators.

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