Abstract
Self-crosslinked ufasomes of conjugated linoleic acid(SCLA ufasomes) were obtained from CLA ufasomes through intravesicular polymerization initiated by mild UV irradiation.Temperature-responsive size and morphology evolutions of the SCLA ufasomes were traced by dynamic light scattering(DLS) and cryo-transmission electron microscope(cryo-TEM),and it was found that not only the vesicular structure of the SCLA ufasomes was stable but also the vesicular volume was expansive hugely with increasing temperature.In vitro release of 5-Fluorouracil(5-FU) from the SCLA ufasomes was evaluated and the results demonstrated that the drug-loading SCLA ufasomes possessed temperature-responsive sustained and controlled release of 5-FU.
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