Temperature monitoring through nanoparticle-activated proton relaxation for magnetic resonance imaging application

Abstract

An effect of temperature on the proton relaxation times in aqueous suspensions of solid-state nanoparticles (NPs) is comparatively investigated for the NPs’ composition varied from pure silicon (Si) with natural isotope content to Si with iron impurities as well as for Si NPs enriched with Si-29 isotope. For all types of the investigated NPs both the longitudinal and transverse relaxation times become shorter compared with that for pure water because of the interaction of electron spin centers in those NPs with nuclear spins of the protons in water molecules. The obtained results allow us to evaluate the temperature sensitivity of NP-based systems for their biomedical applications in magnetic resonance imaging (MRI).