Abstract
Many electrophysiological properties of neuron including firing rates and rhythmical oscillation change in response to a temperature variation, but the mechanism underlying these correlations remains unverified. In this study, we analyzed various action potential (AP) parameters of bursting pacemaker neurons in the abdominal ganglion of Aplysia juliana to examine whether or not bursting patterns are altered in response to temperature change. Here we found that the inter-burst interval, burst duration, and number of spike during burst decreased as temperature increased. On the other hand, the numbers of bursts per minute and numbers of spikes per minute increased and then decreased, but interspike interval during burst firstly decreased and then increased. We also tested the reproducibility of temperature-dependent changes in bursting patterns and AP parameters. Finally we performed computational simulations of these phenomena by using a modified Plant model composed of equations with temperature-dependent scaling factors to mathematically clarify the temperature-dependent changes of bursting patterns in burst-firing neurons. Taken together, we found that the modified Plant model could trace the ionic mechanism underlying the temperature-dependent change in bursting pattern from experiments with bursting pacemaker neurons in the abdominal ganglia of Aplysia juliana.
Highlights
To date, researchers have investigated the effect of temperature on the electrical activity and firing patterns in neurons from many animals, including Aplysia juliana, crabs, crayfish, frogs, lobsters, locusts, snails, and squids [1,2,3,4,5,6,7,8,9]
We examined the effects of temperature changes on the neuronal activity and bursting patterns during several consecutive heating − cooling cycles by using bursting pacemaker neurons which are a proper specimen with capability of long-lasting recording for mathematical modeling
Definition of action potential (AP) parameters in burst-firing neuron The graph in Figure 1A represents the typical bursting patterns of electrical signals shown in Aplysia bursting pacemaker neuron
Summary
Researchers have investigated the effect of temperature on the electrical activity and firing patterns in neurons from many animals, including Aplysia juliana, crabs, crayfish, frogs, lobsters, locusts, snails, and squids [1,2,3,4,5,6,7,8,9]. Few studies on the temperature dependence of action potential (AP) parameters in the R15 bursting pacemaker neuron have been reported [20,21]. They analyzed typical changes of AP parameters in burst-firing neurons by investigating the effect of heat on R15 bursting pacemaker neuron activity as the temperature increased and reported temperaturedependent changes in inter-burst interval, burst duration, Changes in temperature can produce numerous effects on the neural tissue of most organisms. We sought to identify the mechanism underlying temperature-dependent bursting patterns of these neurons by analyzing and comparing the experimental data to computational simulation data calculated by modified Plant equations with temperaturedependent scaling factors, ρ(T) and φ(T)
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