Temperature and Salting out Effects on Nicotine Dissolution Kinetics in Saline Solutions.

Abstract

The dissolution rate of nicotine in aqueous solutions of sodium chloride (NaCl) was investigated at room temperature and 70 °C by quantitatively visualizing the shrinkage rate of microscopic nicotine droplets. Four different salt concentrations were used: 15 wt % (3.0 M), 20 wt % (4.3 M), 25 wt % (5.7 M), and the saturation NaCl concentration of 26 wt % (6.0 M). These results, together with the Epstein–Plesset mathematical model, provided estimates of nicotine’s diffusion coefficient in the NaCl solutions. At room temperature, the dissolution rate of nicotine and diffusion coefficients decreased with increasing NaCl concentration, and below 15 wt %, the dissolution kinetics were too fast to measure accurately via optical microscopy. At the higher temperature of 70 °C, nicotine’s dissolution rate showed a decrease for 15 and 20% NaCl. However, at near-saturation 25% NaCl, nicotine’s dissolution rate did not exhibit significant change for the two temperatures, and for 26%, dissolution was higher at 70 °C than at room temperature.