Abstract
The temperature and magnetic moment depend-ence for assessing localized heating utilizing a new class of Manganese-Zinc-Gadolinium mag-netic nanoparticles was studied. These particles showed heating effect when subjected to alter-nating filed. Alternatively, a new approach was used to get disperse heating without spot heating by using the synthesis of particles at controlled Curie temperature of less than 44oC. The study reports a simple synthesis of Mn0.5Zn0.5GdxFe(2-x)O4 nanoparticles using chemical co- precipita-tion technique. The particles exhibited Curie temperature of 42篊 and high magnitude of mag-netic moments. The particles showed sigmoid behavior of dependence between temperature and magnetic moments. The Nuclear Magnetic Resonance spectroscopy showed T1 depend-ence on temperature in the range of 10-45篊. The particles may have high promise for self con-trolled magnetic hyperthermia application and its monitoring.
Highlights
Heating tumors by nanoparticles and resistance in hypoxic tumor cells to a high temperature is emerging as an effective tool in therapeutic oncology [1]
All the samples were examined by Transmission Electron Microscopy (TEM), X-ray powder diffraction (XRD)
TEM suggested the size of these particles in the range of 20 nm and polymer Polyethylene glycol (PEG) encapsulated nanospheres were measured in the range of 50-70 nm
Summary
Heating tumors by nanoparticles and resistance in hypoxic tumor cells to a high temperature is emerging as an effective tool in therapeutic oncology [1]. Heating of organs and tissues in cancer treatment was first reported [2]. The introduction of nanoparticles enhanced the diagnosis and localization of specific tumor characteristics by multimodal imaging techniques including optical, magnetic resonance, positron emission tomography, computed tomography and X-ray techniques. Feasible clinical therapeutic applicators and hyperthermia equipment were designed. In this direction, colloidal gold-thiol preparations were first reported as effective staining agents to label proteins in both diagnostics such as imaging, blotting, flow cytometry, hybridization assays and gold-thiol hyperthermia agents. Other potential hyperthermic particles are silver, iron, zinc and lanthanum nanoparticles [3,4,5,6,7,8,9,10]
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