Abstract
History acknowledged Ibn Sina, or Avicenna, the author of the highly skilled textbook of medicine "Al-Qanun Fi Al-Tibb" or "The Canon of Medicine", as one of the greatest physicians in medicine. According to this medical textbook, the explanation of the existence of a cold temperament for sleep was that during sleep hours, people tended to have a movement of the nature of the body toward the inside, which caused the body to become cold during sleep. Temperament determination for molecules, including drugs, has proved several applications. The present study tried to demonstrate that the multitasking melatonin molecule, as a sleep related hormone, had a cold temperament. The consideration of this temperament for melatonin had the potential to connect and integrate Iranian traditional medicine to current medicine, and also opened new frontiers for the physiopathology of modern sleep medicine, based on traditional medicine.
Highlights
Heretofore, appreciable assays and efforts have been made by the publishers and authors of this journal to demonstrate the effect of different alternative medicinal plants on sleep improvement (Akanmu et al, 2005; Bum et al, 2004; Bum et al, 2011; Moto et al, 2011)
This study describes melatonin temperament from the perspective of the Persian medicine pioneer Ibn Sina, known in the Europe as Avicenna (980-1037 AD )
Melatonin (N-acetyl-5-methoxy-tryptamine), a hormone produced in the pineal gland in the brain, regulates a number of physiological processes either by its powerful ability to scavenge reactive oxygen species, interact with intracellular molecules or via activation of the G proteincoupled melatonin receptors, MT1 and MT2
Summary
Heretofore, appreciable assays and efforts have been made by the publishers and authors of this journal to demonstrate the effect of different alternative medicinal plants on sleep improvement (Akanmu et al, 2005; Bum et al, 2004; Bum et al, 2011; Moto et al, 2011). This study describes melatonin temperament from the perspective of the Persian medicine pioneer Ibn Sina, known in the Europe as Avicenna (980-1037 AD ). In the concept of Persian medicine, everything or object in the universe is composed of four elements (Air, Water, Fire and Earth ).
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