Abstract
Temozolomide is the only drug approved for the treatment of malignant brain tumors. The sensitivity of Temozolomide-Succinic acid and Temozolomide-Oxalic acid cocrystals (TMZ-SA and TMZ-OA) in inhibiting the proliferation and growth of human glioblastoma malignant cell lines U373, U87 and LN18 is comparable to the reference drug. Both TMZ-SA and TMZ-OA cocrystals are stable to long term storage (white color powder) whereas TMZ becomes tan brown within 2 months (indicative of degradation). These pharmaceutical cocrystals combine the desirable features of hyrolytic stability, good dissolution and cytotoxic activity for further preclinical studies. Inhibition of human glioblastom cell line U87 proliferation by Temozolomide-Succinic acid cocrystal. .
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Schedule a callMore From: Proceedings of the National Academy of Sciences, India Section A: Physical Sciences
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