Abstract
BackgroundPolycystic Ovary Syndrome (PCOS) often present metabolic disorders and hyperandrogenism (HA), facts that may influence the telomere length (TL).AimsTo compare the absolute TL (aTL) between women with PCOS and control women, and their association with the presence of obesity and HA parameters.Materials and methodsThe PCOS group included 170 unrelated women outpatients and the control group, 64 unrelated donor women. Anthropometric, biochemical-clinical parameters and androgen profile were determined. The PCOS patients were divided accordingly to the presence of obesity and androgenic condition. The aTL was determined from peripheral blood leukocytes by Real Time quantitative PCR.ResultsWomen with PCOS exhibited a significantly longer aTL than controls after age adjustment (p=0.001). A stepwise multivariate linear regression in PCOS women, showed that WC (waist circumference) contributed negatively (b=-0.17) while testosterone levels contributed positively (b=7.24) to aTL. The non-Obese PCOS (noOB-PCOS) presented the longest aTL when compared to controls (p=0.001). Meanwhile, the aTL was significantly higher in the hyperandrogenic PCOS phenotype (HA-PCOS) than in the controls (p=0.001) and non hyperandrogenic PCOS phenotype (NHA-PCOS) (p=0.04). Interestingly, when considering obesity and HA parameters in PCOS, HA exerts the major effect over the aTL as non-obese HA exhibited the lengthiest aTL (23.9 ± 13.13 Kbp). Conversely, the obese NHA patients showed the shortest aTL (16.5 ± 10.59 Kbp).ConclusionsWhilst a shorter aTL could be related to the presence of obesity, a longer aTL would be associated with HA phenotype. These findings suggest a balance between the effect produced by the different metabolic and hormonal components, in PCOS women.
Highlights
Polycystic ovary syndrome (PCOS), one of the most common gynecological endocrine diseases, affects 6%–20% of women in their reproductive age [1]
We carried out a retrospective study with 170 PCOS patients, unrelated women recruited from attending the Endocrine Division of the Hospital Durand, Buenos Aires, Argentina, from 2006 to 2016
PCOS patients had higher body mass index (BMI), weight, waist circumference (WC), and higher levels of Total cholesterol (TC), LDL-C, TG, Glucose, Insulin, Homeostasis Model Assessment (HOMA)-IR and lower levels of Quantitative Insulin Sensitivity Check index (QUICKI). These differences remained significant after adjusting for age
Summary
Polycystic ovary syndrome (PCOS), one of the most common gynecological endocrine diseases, affects 6%–20% of women in their reproductive age [1]. Its clinical presentation is heterogeneous, and, according to the Rotterdam criteria, clinically defined by the presence of two or more of the following features: oligo- or anovulation, clinical and/or biochemical hyperandrogenism (HA), and polycystic ovarian morphology [2]. In this way, the Rotterdam criteria defines four phenotypes, three of which present HA (HA-PCOS phenotypes) and one normo androgenic phenotype (NHA-PCOS phenotype) [2, 3]. Obesity worsens the reproductive and metabolic features in PCOS women through increased insulin resistance and inflammation [5] In this way, obesity promotes dyslipidemia and anovulation associated with PCOS [6]. Polycystic Ovary Syndrome (PCOS) often present metabolic disorders and hyperandrogenism (HA), facts that may influence the telomere length (TL)
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