Abstract
Some previous studies suggested telomere length was associated with the risk of ischemic stroke (IS). The aim of this study was to further confirm the association between relative telomere length (RTL) and risk of IS and to especially explore its correlation with the risk of high-risk stroke population in southern Chinese Han. RTL was determined by using real-time quantitative polymerase chain reaction from 400 ischemic stroke patients, 409 high-risk stroke populations and 399 healthy controls. The correlations between the controls and the risk of high-risk and ischemic stroke were evaluated by using an unconditional logistic regression. IS patients have shown longer RTL than controls (median1.52vs1.11, p60 years) and gender suggested that the first and second tertile of RTL were correlated with the risk of IS in each group when the second tertile was used as a reference. However, the increased risk for high-risk stroke populations were only presented in the first tertile of RTL in the age≤60 years and female groups. the RTL was associated with an increased risk of ischemic stroke, while it elevated the risk of high-risk stroke in some specific subpopulations.
Highlights
Stroke is a global health problem and is the second commonest cause of death and a leading cause of adult disability worldwide [1, 2]
As compared with the second tertile, the first and third tertile were associated with the elevated risks of ischemic stroke (OR=2.88, 95% confidence interval (95%CI) 1.88-4.41, p
Further analysis stratified by age and gender suggested that the first and second tertile of relative telomere length (RTL) were correlated with the risk of ischemic stroke (IS) in each group when the second tertile was used as a reference
Summary
Stroke is a global health problem and is the second commonest cause of death and a leading cause of adult disability worldwide [1, 2]. A recent Chinese study has shown that the annual mortality from stroke was about 157 per 100000 which exceedsheart disease, becoming the leading cause of death and adult disability [4]. Due to the huge economic and social burden caused by stroke, it is vital to identify the biomarkers aiding in both prediction and prevention of this disease, excluding the traditional risk factors. Cellular senescence parallels the development of atherosclerosis and other pathologies in the vasculature; it is likely to have a core role in cardiovascular disease [9]. Leucocyte telomere length (LTL) can be considered a predictor of vascular ageing, and further indicate the prediction of atherosclerosis and ischemic stroke
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
