Abstract
Telomere shortening and the resulting cellular senescence promotes ageing in mammals. This study showed that administration (via an adeno-associated virus) of telomerase reverse transcriptase (TERT) — an enzyme that maintains the length of telomeres — to old mice decreased the incidence of age-related osteoporosis and glucose intolerance, improved neuromuscular function and partially improved memory without increasing the incidence of cancer. Furthermore, TERT therapy extended the lifespan of adult and aged mice by a median of 24% and 13%, respectively, showing the feasibility of gene therapy for ageing.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
