Abstract
Hepatic interstitial cells play a vital role in regulating essential biological processes of the liver. Telocytes (TCs), a novel type of interstitial cells firstly identified by Popescu and his coworkers, have been reported in many tissues and organs, but not yet in liver (go to http://www.telocytes.com). We used transmission electron microscopy and immunofluorescence (double labelling for CD34 and c-kit/CD117, or vimentin, or PDGF Receptor-α, or β) to provide evidence for the existence of TCs in mice liver. The distribution of TCs in liver was found to be of similar density in the four hepatic lobes. In conclusion, here we show the presence of TCs in mice liver. It remains to be determined the possible roles of TCs in the control of liver homeostasis and regeneration, the more so as a close special relationship was found between TCs and hepatic putative stem (progenitor) cells.
Highlights
IntroductionTelocytes (TCs) are a novel type of stromal cells of mesenchymal origin firstly identified by Popescu’s group [1,2,3,4,5,6,7,8,9,10,11,12,13,14] and adopted by other laboratories worldwide (go to http://www.telocytes.com) [15,16,17,18,19,20,21,22,23,24,25,26]
This study was aimed to investigate the existence of TCs in the liver by transmission electron microscopy (TEM) as this technique assures the precise identification of TCs [30]
Transmission electron microscopy examination is a golden standard for the identification of TCs [1, 4, 5, 30]
Summary
Telocytes (TCs) are a novel type of stromal cells of mesenchymal origin firstly identified by Popescu’s group [1,2,3,4,5,6,7,8,9,10,11,12,13,14] and adopted by other laboratories worldwide (go to http://www.telocytes.com) [15,16,17,18,19,20,21,22,23,24,25,26]. As a distinct population of interstitial cells, TCs have been documented in the interstitial space of many organs and tissues in mammalian [2,3,4,5,6,7,8,9,10,11,12,13,14,15]. These organs include cavitary ones and non-cavitary organs like pancreas [30]. It remains to be determined that TCs are present in the liver
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
