Abstract
1. Nitrous oxide anaesthesia was supplemented with a 50:1 mixture of R-4749 and R-4263 as well as muscle relaxants in a selected group of poor-risk patients scheduled for prolonged surgery. The mean anaesthetic time/dose curve for these subjects has been calculated. 2. The results indicate that the neuroleptic anaesthesia requirements are subject to the same limiting factors as other intravenous anaesthetics and that the drugs are relatively slowly distributed and metabolized in the body. 3. Attention is called to the fact, among other peculiarities, that patients in this series retained more of their consciousness than with other intravenous anaesthetics and that they tolerated their endotracheal tubes for substantial periods after awakening. These characteristics suggest special indications for the anaesthetic in geriatric surgery, in patients who are marginally conscious preoperatively, and in those who might benefit from ventilatory assistance in the immediate postanaesthetic period.
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