Abstract
Objective: Renin-angiotensin system is associated with many vascular diseases. This study aims to explore the protective effect of telmisartan, Angiotensin type 1 receptor blocker, on pulmonary arterial remodeling induced by low ambient temperature in broiler chickens. Methods: Ninety chickens were randomly divided into 3 groups (n=30), including control group, low temperature group and telmisartan group. Chickens in low temperature group and telmisartan group were exposed to low ambient temperature from 14 days of age until 45 days of age; chickens in telmisartan group were gavaged with telmisartan 5 mg/kg once daily for thirty days. The pulmonary arterial systolic pressure was measured with right catheterization method. Wet lung weight index and right ventricular hypertrophy index were evaluated. Small pulmonary artery wall thickness and elastic fibers was determined respectively by H-E staining and Weight staining. Proliferating Cell Nuclear Antigen (PCNA)-positive cells were determined by Immunohistochemical staining. Results: It showed that pulmonary arterial systolic pressure, wet lung weight index and right ventricular hypertrophy index, small pulmonary artery wall thickness, elastic fibers and PCNA expression increased significantly in Low temperature group compared with control group and telmisartan group. Conclusion: Telmisartan can protect broiler chickens from pulmonary arterial remodeling induced by low ambient temperature
Highlights
Pulmonary Arterial Hypertension (PAH) is a debilitating disorder characterized by progressive narrowing of the pulmonary arterioles, which leads to increased resistance to the flow of blood from right ventricle to the lungs and eventually results in right ventricular failure and death
Chickens in Control group were raised in normal temperature; Chickens in Low temperature group and Telmisartan group were exposed to low ambient temperature from 14 days of age until 45 days of age; at the same time, chickens in Telmisartan group were gavaged with telmisartan (Jiangsu nations biochemical medicine co., LTD; Approved by the enterprise: H20050715) 5 mg/kg by gavage once daily for thirty days
The pulmonary arterial pressure in low temperature group was higher than control group and telmisartan group (p
Summary
Ninety chickens were randomly divided into 3 groups (n=30), including control group, low temperature group and telmisartan group. Chickens in low temperature group and telmisartan group were exposed to low ambient temperature from 14 days of age until 45 days of age; chickens in telmisartan group were gavaged with telmisartan 5 mg/kg once daily for thirty days. The pulmonary arterial systolic pressure was measured with right catheterization method. Wet lung weight index and right ventricular hypertrophy index were evaluated. Small pulmonary artery wall thickness and elastic fibers was determined respectively by H-E staining and Weight staining. Proliferating Cell Nuclear Antigen (PCNA)-positive cells were determined by Immunohistochemical staining
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