Abstract
The tellurium doped zinc imidazole framework (Te@ZIF-8) is prepared by a two-step hydrothermal strategy for the electrochemical sensing of hydrogen peroxide. Material is characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). The electrochemical characterization of the MOF modified electrode is done by a three-electrode system. Electrochemical sensing of hydrogen peroxide is made by cyclic voltammetry, amperometry, and impedance measurements. Results demonstrate that Te@ZIF-8 shows a detection limit of 60 µM with linearity up to 0.98855. Material is stable to 1000 cycles with no significant change in electrochemical response. Amperometry depicts the recovery of hydrogen peroxide from human serum up to 101%. Impedance curve reveals the surface of Te@ZIF-8-GCE (glassy carbon electrode) as porous and rough and an interface is developed between analyte ions and the sensing material. Finally, the modified electrode is used for the quantitative determination of hydrogen peroxide from serum samples of pancreatic cancer patients, diagnosed with CA 19-9.
Highlights
Cancer is a leading cause of death worldwide
Te@ZIF-8 is characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), thermogravimetric (TGA) analysis, and differential scanning calorimetry (DSC)
The first curve at 100 °C is attributed to moisture, the second change is observed around 250 °C to 350 °C indicates the decomposition of Metal–organic frameworks (MOFs) structure
Summary
Cancer is a leading cause of death worldwide. Cancer cells have abnormalities in their genetic sequences and in their patterns of gene expression, and uncontrolled proliferation is the hallmark of cancer cells. Tellurium doped zinc imidazole framework (Te@ZIF-8) is employed as a catalyst by depositing on glassy carbon electrode for the electrochemical sensing of hydrogen peroxide from biological samples. Impedance studies are based on resistive or capacitive transduction of the sensors and are carried out on Te@ZIF-8-GCE for hydrogen peroxide sensing (Fig. 2). Reduction and oxidation curves explain the redox activity of electrode material in 0.1 M PBS (pH 7) containing hydrogen peroxide.
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