Abstract
BackgroundA growing need exists for neuroscience platforms that can perform simultaneous chronic recording and stimulation of neural tissue in animal models in a telemetry-controlled fashion with signal processing for analysis of the chronic recording data and external triggering capability. We describe the system design, testing, evaluation, and implementation of a wireless simultaneous stimulation-and-recording device (SRD) for modulating cortical circuits in physiologically identified sites in primary somatosensory (SI) cortex in awake-behaving and freely-moving rats. The SRD was developed using low-cost electronic components and open-source software. The function of the SRD was assessed by bench and in-vivo testing.ResultsThe SRD recorded spontaneous spiking and bursting neuronal activity, evoked responses to programmed intracortical microstimulation (ICMS) delivered internally by the SRD, and evoked responses to external peripheral forelimb stimulation.ConclusionsThe SRD is capable of wireless stimulation and recording on a predetermined schedule or can be wirelessly synchronized with external input as would be required in behavioral testing prior to, during, and following ICMS.
Highlights
A growing need exists for neuroscience platforms that can perform simultaneous chronic recording and stimulation of neural tissue in animal models in a telemetry-controlled fashion with signal processing for analysis of the chronic recording data and external triggering capability
A growing need exists for neuroscience platforms that can perform simultaneous chronic recording and stimulation of neural tissue in a wireless fashion together with signal processing for analysis of the chronic recording data
We reported that repetitive stimulation of layer V neurons in the forepaw barrel subfield in rat Primary somatosensory cortex (SI) cortex strengthens interhemispheric connections between homotopic sites and leads to expression of previous ineffective ipsilateral input
Summary
A growing need exists for neuroscience platforms that can perform simultaneous chronic recording and stimulation of neural tissue in animal models in a telemetry-controlled fashion with signal processing for analysis of the chronic recording data and external triggering capability. We describe the system design, testing, evaluation, and implementation of a wireless simultaneous stimulation-and-recording device (SRD) for modulating cortical circuits in physiologically identified sites in primary somatosensory (SI) cortex in awake-behaving and freely-moving rats. Whereas wireless systems are less intrusive and extend the range of motion, they often require larger and more complex designs with shorter operating times, and less data bandwidth [2,3,4,5]. A growing need exists for neuroscience platforms that can perform simultaneous chronic recording and stimulation of neural tissue in a wireless fashion together with signal processing for analysis of the chronic recording data. We reported that repetitive stimulation of layer V neurons in the forepaw barrel subfield in rat SI cortex strengthens interhemispheric connections between homotopic sites and leads to expression of previous ineffective ipsilateral input
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